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Orphan Drugs: Top 10 Chemotherapy And Targeted Cancer Products By US Sales

August 5, 2014

In the August 2014 issue of Medical Marketing & Media (MM&M), the publication reviews advances in cancer treatment using immunotherapy and discusses the future of these new agents in the fight against cancer. Per the article, recent research indicates that:

 “… immunotherapy – once perceived as an interesting treatment for a handful of cancer tumors – may be effective against a much wider range of cancers. Moreover, the research is being greeted by an eager FDA, which a few years back created a fast-track approval program – known as Breakthrough Therapy Designation – to bring life-threatening drugs to market much more quickly.”  

Of the 5 FDA Breakthrough Therapy Designations (BTDs) receiving approval (as of 07/23/14), 4 or 80% are for an oncology indication. Of the 49 FDA BTDs (as of 07/21/14), approximately 47% are for an oncology indication.

The following chart shows the top 10 chemotherapy and targeted cancer products (by US Sales – 2013), that have FDA Orphan Drug Designations (ODDs) :

Orphan Drugs: Top 10 Chemotherapy/Targeted Cancer Products By US Sales (2013)

Rank Product Manufacturer US Sales ($ Millions * # of FDA Orphan Drug Designations(ODDs) **
1 Rituxan Genentech/Roche $3,299.8 4
2 Avastin Genentech/Roche $2,697.4 8
3 Herceptin Genentech/Roche $1,945.7 2
4 Gleevec Novartis $1,900.3 7
5 Alimta Eli Lilly $1,197.1 1
6 Xgeva Amgen $788.6 2
7 Afinitor Novartis $720.7 6
8 Treanda Cephalon/Teva $681.4 2
9 Erbitux BMS/Imclone $651.6 2
10 Tarceva Genentech/Roche $641.6 1


* Sales, IMS Health (per MM&M article chart)

** # of FDA ODDs from FDA’s Orphan Drug Product Designation Database (provided by the Orphan Druganaut Blog).

For the other rankings, please reference the article.

Please Note: “3D Bar Graph Meeting” by “The Gold Guys Blog” [CC-BY-SA-2.0] via Wikimedia Commons.

Copyright © 2012-2014, Orphan Druganaut Blog. All rights reserved.

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